Sakurasou no Pet na Kanojo: Mine

Yuuko Kanda gazes at a distracted Sorata Kanda with sparkles in her eyes and around her head

Sorata Kanda lives in a co-ed dormitory with many pretty girls, much to the dismay of his possessive and adoring little sister, Yuuko.
From the anime series Sakurasou no Pet na Kanojo (The Pet Girl of Sakurasou)

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Aho-Girl: Pride and Joy

Akuru Akutsu smiles while looking at a happy Ruri Akutsu

Akuru Akutsu loves doing two things: doting on his little sister, Ruri, and studying for school.
From the anime series Aho-Girl

Happy Lesson: Picture Perfect

Minazuki Rokumatsuri, Chitose Hitotose, and Hazuki Yazakura are all smiling and looking forward

Hazuki Yazakura has a different last name than her younger brother, Chitose Hitotose, and younger sister, Minazuki Rokumatsuri, because they’re orphans who became self-adopted siblings.
From the anime series Happy Lesson

Sunrise on 2018

At sunset, Chitose Hitotose holds Minazuki Rokumatsuri on his shoulders, while Hazuki Yazakura walks alongside them.

Image from the anime series Happy Lesson

Ore no Imouto ga Konnani Kawaii Wake ga Nai: What?

An annoyed Kirino Kosaka glares at a surprised Kyosuke Kosaka

Kirino Kosaka forces her older brother, Kyosuke, to give her life counseling advice about how she can be more open about her hobbies. It also serves as a way to strengthen their bonds as siblings after years of neglect.
From the anime series Ore no Imouto ga Konnani Kawaii Wake ga Nai. (My Little Sister Can’t Be This Cute.)

Eromanga Sensei: Fairy Island Folk

Chris Yamada and Elf Yamada standing in front of the front of a boat on a summer day

Chris Yamada is the executive editor for his little sister, the light novel author known publicly as Elf Yamada. He has to keep an eye on her to ensure she’s actually working because she’s known to be lazy and miss her deadlines.
From the anime series Eromanga Sensei

Tsugumomo: Overactive Imagination

A blushing Kasumi Kagami, garbed in a white shirt andd pink apron, holds herself and acts surprised. Kazuya Kagami looks at her, unamused, in a red T-shirt and blue shorts.

With their father always working and their mother having passed away, Kasumi Kagami assumed the responsibility of taking care of her younger brother, Kazuya. She can be a bit obsessive when it comes to his safety and well-being, though. (And from his perspective, the less said about her desire to tend to his physical needs, the better.)
From the anime series Tsugumomo