Dib Membrane loves studying the paranormal and is the first person to recognize the alien threat to Earth. His little sister, Gaz, however, doesn’t care about any of this because he’s annoying and the alien’s an idiot.
From the Nickelodeon series Invader Zim
Like most teenagers, Summer Smith and her little brother, Morty, find each other annoying, but when trouble happens, they look out for one another.
From the Adult Swim series Rick and Morty
There are eleven children in the Loud household: Lori the eldest is always on her phone; Leni the second eldest is fashionable and ditzy; Luna is a rock musician; Luan is an aspiring comedian; Lynn is an athlete who loves sports; Lincoln the middle child is the only boy; Lucy is a pale-skinned goth; Lana is a tomboy who enjoys building and fixing things; her twin sister, Lola, loves wearing pink dresses; Lisa is a child prodigy, and Lily is a baby.
From the Nickelodeon series The Loud House
Even Charlie Brown has good days sometimes, though little sister Sally probably wishes her Sweet Babboo was there instead.
From the series Peanuts
Ben just wants to return home, but it’s his silent sister, Saoirse, that may hold the key to reuniting their family.
From the movie Song of the Sea
Dipper and Mabel Pines work together to uncover the truth.
From the Disney series Gravity Falls