The aggressive Carossa and the cautious Melissa are twins who fight for the Claw Man as members of The Original Seven.
From the anime series Gun x Sword
Ravus Nox Fleuret, the former prince of Tenebrae, feels differently about the Lucian kings than his younger sister, Lunafreya, does.
From the video game Final Fantasy XV
Kozue Kusanagi’s words and actions had a deep and lasting impact on her little brother Kei’s teenage life.
From the anime series Onegai Teacher (Please Teacher!)
Yoko Inokuma loves her little brother Kota and little sister Mitsuki, even if the young twins say they don’t like her. They’re big liars, and she knows it.
From the anime series Kiniro Mosaic (KINMOZA!)
The son and oldest child of the Enomoto household is a NEET (Not in Education, Employment, or Training) who stays home all day long, whereas the younger daughter, Yuiko, is the former president (and current vice president) of her school’s student council. She’s kind and understanding to him but hot-headed toward pretty much everyone else. When they were children, he teased her a lot, but as an adult, he’s a masochist. Really, the only thing they have in common is their long red hair.
From the anime series Love Lab
Tanaka is the laziest, most apathetic person to ever (not) walk the earth, but Rino, his much more active little sister, loves him all the same.
From the anime series Tanaka-kun wa Itsumo Kedaruge (Tanaka-kun is Always Listless)
Jun Furuya is idolized by his little sister, Hotaru. As such, she is extremely possessive of him and aggressive toward any girl who tries to get close to him.
From the anime series Tsurezure Children (Tsuredure Children)
Shoutarou Torii and his little sister, Moa, do not get along. He finds her rude and mean most of the time, especially when she calls him “baldy”, while she considers him to be loud, annoying, and shamelessly perverted. That said, he won’t hesitate to protect her if she’s in trouble.
From the anime series Saikin, Imouto no Yousu ga Chotto Okashiinda ga. (Recently, My Sister is Unusual)
Rich kid Miku Sugisaki is haughty and loves to brag about her expensive clothes and possessions, while her younger brother, Ryuuta, is ill-mannered and selfish. That said, she does try to make sure he stays away from bad influences.
From the anime series Mitsudomoe