A Nightmare on Elm Street 4: The Dream Master: Swish!

Rick Johnson does a celebratory fist pump with both hands while Alice Johnson smiles

Rick Johnson, a Karate enthusiast, and his daydreaming younger sister, Alice, work together to fight against a supernatural being who kills people in their dreams.
From the movie A Nightmare on Elm Street 4: The Dream Master

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Invader Zim: No Room for Doom

Dib Membrane and Gaz Membrane standing on a futuristic purple and gray walkway

Dib Membrane loves studying the paranormal and is the first person to recognize the alien threat to Earth. His little sister, Gaz, however, doesn’t care about any of this because he’s annoying and the alien’s an idiot.
From the Nickelodeon series Invader Zim

Kaibutsu Oujo: Warriors

Riza Wildman in the middle flanked by werewolf Lobo on the left and human Lobo on the right

Lobo Wildman was a pure breed werewolf who fought with pride and honor and always sought to instill those values in his beloved half-werewolf, half-human little sister, Riza.
From the anime series Kaibutsu Oujo (Princess Resurrection)

The Evil Dead: Worried

A disheveled Cheryl Williams looks at Ash Williams

Terrible things happen to Ash Williams and his sister, Cheryl, when they visit an isolated cabin in the woods.
From the movie The Evil Dead

Get Out: Looking Down

Jeremy Armitage and Rose Armitage looking downward

Like many children, Rose and Jeremy Armitage are dedicated to the well-being of their family.
From the movie Get Out

Suzumiya Haruhi no Yuuutsu: Another Beautiful Day

Kyon holding the handlebars of a bike while dressed in a suit and tie. Kyon's sister smiling while grabbing her bookbag. Both are standing outside.

Kyon is an ordinary high school student who has to deal with espers, aliens, time travelers, and other beings with special powers–all while making sure his little sister remains happy and oblivious to that.
From the anime series Suzumiya Haruhi no Yuuutsu (The Melancholy of Suzumiya Haruhi)

Rick and Morty: Look at Me!

Summer Smith stands in front of a large hole in the wall of a house and holds a remote controller device in one hand. Morty Smith looks back at her.

Like most teenagers, Summer Smith and her little brother, Morty, find each other annoying, but when trouble happens, they look out for one another.
From the Adult Swim series Rick and Morty