Your source for brother and sister love
Candace Flynn is determined to make sure her little brother Phineas and their step-brother Ferb get in trouble with their mother over their daily, over-the-top activities during summer vacation.
From the TV series Phineas and Ferb
Hansel is the Otogi Academy student council president, and Gretel, his younger sister, is the student council secretary. They adore each other wholeheartedly.
From the anime series Ookami-san to Shichinin no Nakama-tachi (Okami-San and Her Seven Companions)
Touka Fushimi can see the gods, an ability his younger sister, Inari, also acquires. When she befriends a local goddess and is given the divine power to transform into other people, he is suspicious of their relationship.
From the anime series Inari, Konkon, Koi Iroha (Inari Kon Kon)
Children of the Madrigal family are granted special abilities. Pepa’s mood can affect the weather, Bruno can see into the future, and Julieta can heal physical ailments with her cooking.
From the movie Encanto
Ichiko Rokujou is a teacher who enjoys her duties, her students, and (the rare appearance of) her little brother.
From the anime series Kakushigoto
When Nobunaga Oda suddenly finds himself with a girl who swears to become his wife, his little sister Ichika is there to keep him in line.
From the anime series Nobunaga-sensei no Osanazuma (Nobunaga Teacher’s Young Bride)
Matsuboshi Raidou has such a difficult time making friends, even though he is a nice guy, that even his little sister sometimes worries about him.
From the anime series Aharen-san wa Hakarenai (Aharen is Indecipherable)
Miko Yotsuya has the ability to see the ghastly spirits that exist amid her everyday life. She’s terrified of them but acts like she can’t see them, only reacting when she’s safe. Her little brother, Kyousuke, who can’t see them, just thinks she acts weird.
From the anime series Mieruko-chan
Jirukoma, the appointed head of a settlement of refugees who have lost their lands to the Demon Lord, and Komain, his younger sister, have differing opinions on the future of their people: one wants to make a new home, while the other wants to fight to reclaim their old one.
From the anime series Genjitsu Shugi Yuusha no Oukoku Saikenki (How a Realist Hero Rebuilt the Kingdom)
Futaba Yoshinaga was already a strong-willed tomboy who teased her mild-mannered older brother, Kazumi, and attacked people with a flying kick. Being forcibly given a talking stone gargoyle that insisted on guarding their house only intensified her actions.
From the anime series Yoshinaga-sanchi no Gargoyle (Gargoyle of Yoshinaga House)
Sister/Brother Complex 