Friends: There For You

Monica Geller and Ross Geller sitting in a garage

Ross Geller and his kid sister, Monica, might not have gotten along growing up and still occasionally compete and argue like children, but as adults, they are now best friends who look after each other during life’s ups and downs.
From the television series Friends

Aa! Megami-sama!: Blueprints

Keiichi Morisato sitting on the ground and holding a large piece of paper. Megumi Morisato is seated next to him and looking at it.

Keiichi Morisato and his little sister, Megumi, are both skilled mechanics and exceptional race drivers who go to school at the Nekomi Institute of Technology.
From the anime series Aa! Megami-sama! (Oh My Goddess!)

Game of Thrones: The Last Dragons

Viserys Targaryen and Daenerys Targaryen in front of a light brown curtain

After the death of the king in Robert’s Rebellion, Prince Viserys Targaryen and his little sister, Princess Daenerys, fled across the Narrow Sea in exile. They hope to return to Westeros one day and reclaim their father’s throne.
From the television series, Game of Thrones, adapted from George R. R. Martin’s A Song of Ice and Fire novels

Akiba’s Trip: The Animation: Interesting Times

Tamotsu Denkigai and Niwaka Denkigai smiling and sitting on a bench in front of bushes

Tamotsu Denkigai and his little sister, Niwaka, are otakus who love the Akihabara shopping district, and they battle against monsters called “Bugged Ones” that are trying to destroy it.
From the anime series Akiba’s Trip: The Animation

Shoujo Kakumei Utena: Yellow Rose and Red Rose

Nanami Kiryuu and Touga Kiryuu standing against a gray backdrop

Touga Kiryuu is president of Ootori Academy’s student council and is popular among the school’s female population. His possessive little sister, Nanami, however, only wants him to pay attention to her and punishes any girls who try to get close to him.
From the anime series Shoujo Kakumei Utena (Revolutionary Girl Utena)

Fire Emblem Heroes: Defenders of Zenith

Princess Sharena and Prince Alfonse stand in front of an emblem

Alfonse and Sharena, the prince and princess of the holy kingdom of Askr, battle against the invading Emblian Empire.
From the video game Fire Emblem Heroes

Death Note: Study Session

Light Yagami helps Sayu Yagami study at a desk while Ryuk the shinigami relaxes on a bed in the background

When Light Yagami isn’t committing mass murder using a supernatural notebook, he’s a hardworking student who often helps his little sister, Saya, with her homework.
From the anime series Death Note