Kaibutsu Oujo: Warriors

Riza Wildman in the middle flanked by werewolf Lobo on the left and human Lobo on the right

Lobo Wildman was a pure breed werewolf who fought with pride and honor and always sought to instill those values in his beloved half-werewolf, half-human little sister, Riza.
From the anime series Kaibutsu Oujo (Princess Resurrection)

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Suzumiya Haruhi no Yuuutsu: Another Beautiful Day

Kyon holding the handlebars of a bike while dressed in a suit and tie. Kyon's sister smiling while grabbing her bookbag. Both are standing outside.

Kyon is an ordinary high school student who has to deal with espers, aliens, time travelers, and other beings with special powers–all while making sure his little sister remains happy and oblivious to that.
From the anime series Suzumiya Haruhi no Yuuutsu (The Melancholy of Suzumiya Haruhi)

Dogtooth: Party of Three

Eldest sister and youngest sister stand while their brother sits and holds a guitar

The overprotective parents of three siblings–eldest daughter, middle brother, and youngest sister–have kept them at home for their entire lives, completely isolating them from the outside world.
From the movie Dogtooth

Fuuka: Table Talk – Part IV

Yuu Haruna looks down while Chitose Haruna looks on

Yuu Haruna doesn’t always get along with his younger sister, Chitose, but they still care for each other in their own way.
From the anime series Fuuka

Fuuka: Table Talk – Part I

Maya Haruna, Yuu Haruna, Hibiki Haruna, and Chitose Haruna standing around a table

The Haruna siblings–Maya, Hibiki, Yuu, and Chitose–live together in an apartment.
From the anime series Fuuka

Friends: There For You

Monica Geller and Ross Geller sitting in a garage

Ross Geller and his kid sister, Monica, might not have gotten along growing up and still occasionally compete and argue like children, but as adults, they are now best friends who look after each other during life’s ups and downs.
From the television series Friends

Aa! Megami-sama!: Blueprints

Keiichi Morisato sitting on the ground and holding a large piece of paper. Megumi Morisato is seated next to him and looking at it.

Keiichi Morisato and his little sister, Megumi, are both skilled mechanics and exceptional race drivers who go to school at the Nekomi Institute of Technology.
From the anime series Aa! Megami-sama! (Oh My Goddess!)