Tsugumomo: Overactive Imagination

A blushing Kasumi Kagami, garbed in a white shirt andd pink apron, holds herself and acts surprised. Kazuya Kagami looks at her, unamused, in a red T-shirt and blue shorts.

With their father always working and their mother having passed away, Kasumi Kagami assumed the responsibility of taking care of her younger brother, Kazuya. She can be a bit obsessive when it comes to his safety and well-being, though. (And from his perspective, the less said about her desire to tend to his physical needs, the better.)
From the anime series Tsugumomo

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Rick and Morty: Look at Me!

Summer Smith stands in front of a large hole in the wall of a house and holds a remote controller device in one hand. Morty Smith looks back at her.

Like most teenagers, Summer Smith and her little brother, Morty, find each other annoying, but when trouble happens, they look out for one another.
From the Adult Swim series Rick and Morty

Servant x Service: Carefree

Kaoru Hasebe smiles and sits with her eyes closed, while Yutaka Hasebe stands in a shirt and tie

Like everyone else in their family, Kaoru Hasebe and her little brother, Yutaka, are both happy-go-lucky civil servants.
From the anime series Servant x Service

Fuuka: Table Talk – Part III

Yuu Haruna looks down at his phone while Hibiki Haruna looks away and smiles

Hibiki Haruna is a college student who enjoys teasing her younger brother, Yuu, about his unfriendly behavior and the amount of time he spends using his phone.
From the anime series Fuuka

Fuuka: Table Talk – Part II

Yuu Haruna looks back as Maya Haruna looks out from the kitchen

Maya Haruna, the oldest daughter and eldest child, looks after her little brother, Yuu, and her two younger sisters while their parents work overseas.
From the anime series Fuuka

Fuuka: Table Talk – Part I

Maya Haruna, Yuu Haruna, Hibiki Haruna, and Chitose Haruna standing around a table

The Haruna siblings–Maya, Hibiki, Yuu, and Chitose–live together in an apartment.
From the anime series Fuuka

3-gatsu no Lion: Butting Heads

Close-up of Kyouko Kouda and Rei Kiriyama looking at each other while frowning

Kyouko Kouda does not get along well with her foster brother, a professional shougi player named Rei Kiriyama. She resents him because her father favored him when they were children, and he both dislikes and likes her negativity towards him because he feels it’s justified.
From the anime series 3-gatsu no Lion (March comes in like a Lion)