Tsugumomo: Overactive Imagination

A blushing Kasumi Kagami, garbed in a white shirt andd pink apron, holds herself and acts surprised. Kazuya Kagami looks at her, unamused, in a red T-shirt and blue shorts.

With their father always working and their mother having passed away, Kasumi Kagami assumed the responsibility of taking care of her younger brother, Kazuya. She can be a bit obsessive when it comes to his safety and well-being, though. (And from his perspective, the less said about her desire to tend to his physical needs, the better.)
From the anime series Tsugumomo

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Digimon Adventure: Ready for Action

Taichi Yagami is standing with his fists raised. Hikari Yagami stands next to him. Both are looking in the same direction.

Taichi Yagami and his younger sister, Hikari, along with their digital monster companions, are among those destined to save the Digital World from the forces of evil. (These two DigiDestined are also known by the names Tai Kamiya and Kari Kamiya in other heroic tales.)
From the anime series Digimon Adventure

The Savages: Awkwardness

Jon Savage and Wendy Savage both standing in an open doorway. She's holding a coffee and a balloon.

Jon Savage and his younger sister, Wendy, are adult siblings who grew apart over the years but have come together again to take care of their estranged, ailing father.
From the movie The Savages (2007)

Shi Mao and Shi Fen in Ani ni Tsukeru Kusuri wa Nai!: Good Times

Shi Mao and Shi Fen standing with their arms crossed in front of a large clock

Shi Fen’s lazy and selfish actions constantly annoy his athletic younger sister, Shi Mao and cause her to beat him up. However, at the end of the day, they still get along and look out for each other.
From the anime series Ani ni Tsukeru Kusuri wa Nai! (There’s No Cure for My Brother!)

A Nightmare on Elm Street 4: The Dream Master: Swish!

Rick Johnson does a celebratory fist pump with both hands while Alice Johnson smiles

Rick Johnson, a Karate enthusiast, and his daydreaming younger sister, Alice, work together to fight against a supernatural being who kills people in their dreams.
From the movie A Nightmare on Elm Street 4: The Dream Master

Invader Zim: No Room for Doom

Dib Membrane and Gaz Membrane standing on a futuristic purple and gray walkway

Dib Membrane loves studying the paranormal and is the first person to recognize the alien threat to Earth. His little sister, Gaz, however, doesn’t care about any of this because he’s annoying and the alien’s an idiot.
From the Nickelodeon series Invader Zim

Kaibutsu Oujo: Warriors

Riza Wildman in the middle flanked by werewolf Lobo on the left and human Lobo on the right

Lobo Wildman was a pure breed werewolf who fought with pride and honor and always sought to instill those values in his beloved half-werewolf, half-human little sister, Riza.
From the anime series Kaibutsu Oujo (Princess Resurrection)