Student council president and Tarot card reader Riri “Lily” Hojo and her little brother, Masaru, an expert card game player, compete as a Hand Shaker pair in order to have their wish granted by god.
From the anime series Hand Shakers
When Lia de Beaumont is found dead, her younger brother, D’Eon de Beaumont, an agent of the French king, investigates the mysterious circumstances behind her demise with help from her spirit.
From the anime series Le Chevalier D’Eon
Nanami Kirishima dotes on her younger brother, Kaito, whom she has taken care of since the death of their parents. When she goes on a long trip to Bolivia, she makes sure people are there to keep an eye on him.
From the anime series Ano Natsu de Matteru (Waiting in Summer)
Rin Sawamura loves drinking, hanging out with her old street gang, and messing with her little brother, Seiji. He, however, hates her devil-may-care behavior.
From the anime series Midori no Hibi (Midori Days)
Sora and his little sister Shiro may be shut-ins in real life, but in the gaming world, they are the top-scoring, undefeated entity known as “Blank.”
From the anime series No Game No Life
Mako Saitou and her little brother, Mao, are both quiet, thoughtful people who can be a bit strange at times.
From the anime series Super Seisyun Brothers
Lottie Gelh’s beloved older brother was a soldier who often had to leave home, and she always missed him when he was away.
From the anime series Soukou no Strain (Strain: Strategic Armored Infantry)
Kanji Sasahara and his little sister, Keiko, are quite different. He’s a shy anime, manga, and video game fan, whereas she’s a blunt talker who’s fashionable and leads a very social life.
From the anime series Genshiken
After having a falling out with her father over her career choices, Maki Midorikawa is content with doing her own thing. However, her little brother Kousuke worries about her and encourages her to reconcile with the family.
From the anime series Sakura Quest
Carmen Cortez and her little brother, Juni, are the unknowing children of retired espionage agents and become spies themselves after their parents are kidnapped.
From the movie Spy Kids