Happy Lesson: Picture Perfect

Minazuki Rokumatsuri, Chitose Hitotose, and Hazuki Yazakura are all smiling and looking forward

Hazuki Yazakura has a different last name than her younger brother, Chitose Hitotose, and younger sister, Minazuki Rokumatsuri, because they’re orphans who became self-adopted siblings.
From the anime series Happy Lesson

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Mobile Suit Gundam: Iron-Blooded Orphans: Squeeze

Biscuit Griffon being hugged by Cookie Griffon and Cracker Griffon at the same time

Biscuit Griffon works for a private security company (and then a mercenary group) in order to make enough money to support his family and send Cookie and Cracker, his younger twin sisters, to school.
From the anime series Mobile Suit Gundam: Iron-Blooded Orphans

Dogtooth: Party of Three

Eldest sister and youngest sister stand while their brother sits and holds a guitar

The overprotective parents of three siblings–eldest daughter, middle brother, and youngest sister–have kept them at home for their entire lives, completely isolating them from the outside world.
From the movie Dogtooth

Joukamachi no Dandelion: The Royal Bunch – Part V

Hikari, Teru, and Shiori Sakurada standing in front of a crowd

Instead of wanting to be a ruler, Hikari Sakurada, the fifth princess, dreams of becoming a singing idol. Similarly, her younger brother, the third prince, Teru, only sees himself as a hero, while Shiori, the sixth princess and youngest child, just likes being with her family.

From the anime series Joukamachi no Dandelion (Castle Town Dandelion)

Shinmai Maou no Testament: Thou Shalt Be Happy

Basara Tojo, Mio Naruse, and Maria Naruse standing outside in front of a building

When his dad suddenly remarries, Basara Tojo finds himself with two younger step-sisters, Mio Naruse (red hair) and Maria Naruse (white hair), who happen to be actual demons.
From the anime series Shinmai Maou no Testament (The Testament of Sister New Devil)

Free!: Admiration

Makoto Tachibana puts his hand on Ren Tachibana's shoulder while Ran Tachibana hugs him

Makoto Tachibana is adored by his little sister, Ran, and her twin brother, Ren.
From the anime series Free!

Kiss x Sis: Merry Christmas!

Twin sisters Ako and Riko Suminoe in Christmas outfits next to their younger brother Keita

Happy Holidays from Sister/Brother Complex!

Twin sisters Ako and Riko Suminoe (left and right, respectively) can surely wipe the troubled expression from their younger stepbrother Keita’s face.
From the anime series Kiss x Sis