The Loud House: Turn Up the Volume

The Loud siblings (Lori, Leni, Luna, Luan, Lynn, Lincoln, Lucy, Lana, Lola, Lisa, and Lily) gathered on and around a couch watching television

There are eleven children in the Loud household: Lori the eldest is always on her phone; Leni the second eldest is fashionable and ditzy; Luna is a rock musician; Luan is an aspiring comedian; Lynn is an athlete who loves sports; Lincoln the middle child is the only boy; Lucy is a pale-skinned goth; Lana is a tomboy who enjoys building and fixing things; her twin sister, Lola, loves wearing pink dresses; Lisa is a child prodigy, and Lily is a baby.
From the Nickelodeon series The Loud House

Baka to Test to Shoukanjuu: Tea for Two

Yuuko Kinoshita and Hideyoshi Kinoshita seated and drinking from a cup

Yuuko Kinoshita and her younger twin brother, Hideyoshi, might look identical, but they’re quite different. She’s an intelligent, prideful, and irritable member of Fumizuki Academy’s top class, whereas he’s a helpful and kind individual whose true passion is acting.
From the anime series Baka to Test to Shoukanjuu

Masou Gakuen HxH: Tough Decisions

Reiri Hida sits in a chair, while Kizuna Hida angrily glares at her from behind

Reiri Hida is both the principal and commander of the Ataraxia military academy. She gives orders to people like her younger brother, Kizuna, who possess a Heart Hybrid Gear weapon armor that can fight against invaders from another world.
From the anime series Masou Gakuen HxH (Hybrid × Heart Magias Academy Ataraxia)

Medaka Box: Class 13 Perverts

Myouri Unzen looks at Myouga Unzen who holds two giant iron balls

Myouga Unzen and her younger brother, Myouri, both possess unique abilities, an affinity for spherical objects, and dirty minds.
From the anime series Medaka Box

The Family Fang: Filming

Baxter Fang holds a camera while he and Annie Fang observe

As adults, Annie Fang and her younger brother, Baxter, are both still trying to come to terms with the fact that their conceptual performance artist parents used them in their controversial, avant-guard work.
From the movie The Family Fang

The 5th Wave: Who’s That?

Cassie Sullivan and Sam Sullivan standing in front of greenery and looking at something

Will Cassie Sullivan and her little brother, Sam, survive the next phase of the alien invasion?
From the movie The 5th Wave

Fullmetal Alchemist: Brotherhood: Bring It On

Alex Armstrong and Olivier Armstrong staring angrily while covered in blood

Don’t mess with Major General Olivier Armstrong or her younger brother Major Alex Armstrong.
From the anime series Fullmetal Alchemist: Brotherhood