Tsugumomo: Overactive Imagination

A blushing Kasumi Kagami, garbed in a white shirt andd pink apron, holds herself and acts surprised. Kazuya Kagami looks at her, unamused, in a red T-shirt and blue shorts.

With their father always working and their mother having passed away, Kasumi Kagami assumed the responsibility of taking care of her younger brother, Kazuya. She can be a bit obsessive when it comes to his safety and well-being, though. (And from his perspective, the less said about her desire to tend to his physical needs, the better.)
From the anime series Tsugumomo

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Mobile Suit Gundam: Iron-Blooded Orphans: Squeeze

Biscuit Griffon being hugged by Cookie Griffon and Cracker Griffon at the same time

Biscuit Griffon works for a private security company (and then a mercenary group) in order to make enough money to support his family and send Cookie and Cracker, his younger twin sisters, to school.
From the anime series Mobile Suit Gundam: Iron-Blooded Orphans

Rick and Morty: Look at Me!

Summer Smith stands in front of a large hole in the wall of a house and holds a remote controller device in one hand. Morty Smith looks back at her.

Like most teenagers, Summer Smith and her little brother, Morty, find each other annoying, but when trouble happens, they look out for one another.
From the Adult Swim series Rick and Morty

Dogtooth: Party of Three

Eldest sister and youngest sister stand while their brother sits and holds a guitar

The overprotective parents of three siblings–eldest daughter, middle brother, and youngest sister–have kept them at home for their entire lives, completely isolating them from the outside world.
From the movie Dogtooth

Servant x Service: Carefree

Kaoru Hasebe smiles and sits with her eyes closed, while Yutaka Hasebe stands in a shirt and tie

Like everyone else in their family, Kaoru Hasebe and her little brother, Yutaka, are both happy-go-lucky civil servants.
From the anime series Servant x Service

Fuuka: Table Talk – Part III

Yuu Haruna looks down at his phone while Hibiki Haruna looks away and smiles

Hibiki Haruna is a college student who enjoys teasing her younger brother, Yuu, about his unfriendly behavior and the amount of time he spends using his phone.
From the anime series Fuuka

Fuuka: Table Talk – Part II

Yuu Haruna looks back as Maya Haruna looks out from the kitchen

Maya Haruna, the oldest daughter and eldest child, looks after her little brother, Yuu, and her two younger sisters while their parents work overseas.
From the anime series Fuuka