Mobile Suit Gundam 00: In Happier Times

A photo wallet card showing Kinue and Saji Crossroad as children

Kinue Crossroad and her little brother, Saji, as children
From the anime series Mobile Suit Gundam 00

Higurashi no Naku Koro ni: Be Careful

Satoshi and Satoko Houjou looking back

Satoshi Houjou looks out for his little sister, Satoko, after tragedy strikes their family, but it’s not easy for either of them.
From the anime series Higurashi no Naku Koro ni (When the Cicadas Cry)

Attack On Titan: Junior High: Shopping Trip

Eren Yeager holds a bag of food as he and Mikasa Ackerman walk away from a convenience store

Eren Yeager hates all titans, seeking revenge after one of them steals and eats his favorite food. Mikasa Ackerman, his strong and steadfast adopted sister, goes along with him to keep him from getting into too much trouble.
From the anime series Shingeki! Kyojin Chuugakkou (Attack on Titan: Junior High)

Final Fantasy IV: Heroes of Mysidia

Porom and Palom pose with their magical staves

Porom is White Mage who specializes in healing and protection spells, while her arrogant twin brother Porom is a Black Mage who focuses on attack spells. Together, they helped save the world from destruction.
From the videogame Final Fantasy IV

Wolf Children: Transformation

Yuki and Ame as young kids/wolf cubs

Yuki and her little brother, Ame, can switch between being a person and an animal because they are the offspring of a human and a werewolf.
From the anime movie Ookami Kodomo no Ame to Yuki (The Wolf Children Ame and Yuki)