Angel Sanctuary: Endless Struggle

Setsuna Mudo, being held back by two men, calls to his younger sister, Sara, who is facing away from him

Setsuna Mudo will go against any force — angel or demon, man or god — so that he and his younger sister, Sara, can be happy.
From the anime series Tenshi Kinryouku (Angel Sanctuary)

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Koi Kaze: At First Blush

Nanoka Kohinata smiles at her flustered older brother Koshiro Saeki

Koshiro Saeki isn’t sure how to act around his much younger sister, Nanoka Kohinata, when they’re reunited after several years of living apart.
From the anime series Koi Kaze (Love Wind)

Himouto! Umaru-chan: Never A Dull Moment

A collage of Taihei and Umaru Doma doing various things

With a little sister like Umaru, Taihei Doma’s life is anything but boring.
From the anime series Himouto! Umaru-chan

They Are My Noble Masters: Recharging

Mihato Uesugi holds her little brother Ren's head to her chest in a warm embrace

Mihato Uesugi and her little brother, Ren, have been through difficult times, but they always feel safe and at ease when they are together, drawing strength from one another.
From the anime series Kimi ga Aruji de Shitsuji ga Ore de (They Are My Noble Masters)